Schizophrenia Research Summary: October 20

In this Research Synthesis, we explore new research on schizophrenia and its association with neurocognition, suicidal ideation, insomnia, and language impairment in multiple groups. different patients.

Age-related differences in neurocognition and suicidal ideation in patients with schizophrenia

This cross-sectional study aimed to investigate the relationship between neurocognition and suicidal ideation in middle-aged and elderly patients with schizophrenia. Research shows that middle-aged and elderly patients with schizophrenia with good visuospatial abilities and attentional function are more likely to have suicidal thoughts. However, no correlation between neurocognition and suicidal ideation was observed in young patients with schizophrenia.

We should pay additional attention to middle-aged and elderly people [patients with schizophrenia] with good neurocognitive abilities, the investigators concluded. There is a need to develop a new and effective intervention that focuses on distracting attention from the disease to reduce the likelihood of suicidal ideation. Further cohort studies are warranted to detect the relationship between neurocognition and suicidal ideation across age groups.

Authority to solve

Wang Q, Tang W, Zhang J, et al. Visuospatial abilities and attention as risk factors for suicidal ideation in middle-aged and elderly patients with schizophrenia: a cross-sectional study.BMC Psychiatry. 2023;23(1):765.

Association between Olanzapine and age, sex and smoking in patients with schizophrenia

This study aimed to investigate the association between cigarette smoking, age, gender and serum olanzapine concentration in patients with schizophrenia. The findings showed that smokers had significantly lower serum concentrations of olanzapine than non-smokers, potentially leading to adverse effects. However, the study found no significant differences in olanzapine concentrations related to patient age or gender.

The investigators concluded that this study demonstrated that smoking is associated with lower serum concentrations of olanzapine. There were no significant differences in serum olanzapine concentrations related to age and sex in patients with schizophrenia.

Authority to solve

Horvat M, Kadija M, avniar A, et al. Association of cigarette smoking, age and sex with serum olanzapine concentrations in patients with schizophrenia.Biochemistry Med (Zagreb). 2023;33(3):030702.

Investigation of the association between insomnia and impaired language ability in patients with schizophrenia

This study investigated the association between insomnia symptoms and language ability in patients with schizophrenia. It revealed that people with schizophrenia who suffered from insomnia exhibited reduced performance on the verbal fluency test (VFT), suggesting a link between insomnia and impaired language skills . These findings imply that addressing insomnia in patients with schizophrenia may enhance cognitive function and quality of life, although limitations of the study, such as side effects, should be considered. Effects of sleep-enhancing drugs.

The researchers concluded that there were significant differences in language ability between schizophrenia patients with insomnia and those without insomnia symptoms. This shows that schizophrenia patients with insomnia are at higher risk of language disorders.

Authority to solve

Linlin W, Ruofei J, Hudan C, et al. Analyzing the correlation between insomnia symptoms and language function in schizophrenia patients.Schizophrenia Res Cogn. 2023;34:100292.

Note: Support from ChatGPT was used to prepare this study.

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